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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EP300
All Species:
19.39
Human Site:
S1232
Identified Species:
35.56
UniProt:
Q09472
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q09472
NP_001420.2
2414
264161
S1232
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
Chimpanzee
Pan troglodytes
XP_515155
2411
263753
S1232
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
Rhesus Macaque
Macaca mulatta
XP_001102844
2414
264251
S1232
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
Dog
Lupus familis
XP_851777
2404
260682
E1233
T
I
S
K
D
Q
F
E
K
K
K
N
D
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P45481
2441
265456
E1269
T
I
S
K
D
Q
F
E
K
K
K
N
D
T
L
Rat
Rattus norvegicus
XP_001076610
2413
263563
S1230
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233888
2444
267496
S1246
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
Frog
Xenopus laevis
NP_001088637
2428
264402
E1259
T
I
S
K
E
Q
F
E
K
K
K
N
D
M
L
Zebra Danio
Brachydanio rerio
XP_001332718
2667
289125
E1241
S
I
N
K
D
Q
F
E
K
K
K
N
D
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524642
3276
340709
S1880
L
G
D
D
P
L
Q
S
Q
T
Q
I
K
K
D
Honey Bee
Apis mellifera
XP_001122031
2606
284119
Q1469
A
I
K
K
E
Q
F
Q
E
M
K
N
D
H
L
Nematode Worm
Caenorhab. elegans
P34545
2056
227161
F1069
S
V
I
D
Y
E
P
F
E
R
C
K
Y
C
M
Sea Urchin
Strong. purpuratus
XP_782558
2635
288594
C1477
T
I
E
K
K
T
F
C
R
K
K
N
D
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
61
N.A.
58.6
94.1
N.A.
N.A.
85.1
60.4
57
N.A.
36.2
43
31.1
39.5
Protein Similarity:
100
99.7
99.5
72.4
N.A.
69.5
96.1
N.A.
N.A.
89.9
71
65.9
N.A.
46.6
54.9
45.6
51.5
P-Site Identity:
100
100
100
73.3
N.A.
73.3
100
N.A.
N.A.
100
73.3
73.3
N.A.
6.6
60
6.6
53.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
N.A.
100
86.6
93.3
N.A.
26.6
66.6
40
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
8
0
0
8
0
% C
% Asp:
0
0
8
16
24
0
0
0
0
0
0
0
85
0
8
% D
% Glu:
0
0
8
0
54
8
0
31
16
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
85
8
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
85
8
0
0
0
0
0
0
0
0
8
0
8
0
% I
% Lys:
0
0
8
85
8
0
0
0
70
39
85
8
8
8
0
% K
% Leu:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
85
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
8
% M
% Asn:
0
0
47
0
0
0
0
0
0
0
0
85
0
0
0
% N
% Pro:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
77
8
8
8
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
47
0
0
0
0
0
% R
% Ser:
16
0
24
0
0
0
0
47
0
0
0
0
0
0
0
% S
% Thr:
70
0
0
0
0
8
0
0
0
8
0
0
0
62
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _